Application | Comment | Organism |
---|---|---|
medicine | the oncogenic role of SIRT6 in skin cancer suggest SIRT6 as a potential target for developing chemopreventive strategies to reduce the skin cancer | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N6T7 | - |
- |
Mus musculus | P59941 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | epidermal | Homo sapiens | - |
skin | - |
Mus musculus | - |
skin | sun-protected normal skin | Homo sapiens | - |
squamous cell carcinoma cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
SIRT6 | - |
Homo sapiens |
SIRT6 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | SIRT6 is upregulated in squamous cell carcinoma | up |
General Information | Comment | Organism |
---|---|---|
malfunction | SIRT6 loss suppresses proliferation and epidermal hyperplasia in mouse skin. Skin-specific deletion of SIRT6 in the mouse inhibits skin tumorigenesis | Mus musculus |
metabolism | SIRT6 upregulates COX-2 levels and acts as an oncogene in skin carcinogenesis | Homo sapiens |
metabolism | SIRT6 upregulates COX-2 levels and acts as an oncogene in skin carcinogenesis | Mus musculus |